Group Leader, CNRS Research Director
Cancer Research Center of Marseille (CRCM), Marseille, France

My group is interested since many years in the link between inflammation, oxidative stress and cancer. This led us to the study of mitochondrial energetic metabolism, the main cell source of energy and free radicals. In that context, I am currently driving a project which aims at deciphering the alterations of mitochondrial metabolism and inflammation in pancreatic cancer, towards the improvement of the knowledge and the development of novel clinical avenues.

The Pancreatic Ductal AdenoCarcinoma (PDAC) is resistant to currently available treatments. Despite progress in our understanding of the physiopathology of this cancer, many aspects remain poorly understood, which impedes the development of novel therapeutic strategies. Among these strategies, targeting metabolic dysregulations of cancer cells is promising. In particular, the mitochondrial metabolism remains poorly explored in cancers despite the central role of these organelles in cell bioenergetics and apoptosis.

The general objective of our project is to unveil the impact of mitochondria in pancreatic cancer cells aggressiveness and resistance to therapy, allowing the development of new preclinical assays targeting mitochondria.