Laurent Bartholin has been working on Transforming Growth Factor Beta (TGF?) signaling for 20 years. TGF? is the archetype of the transforming growth factor superfamily composed of polypeptides involved in embryonic development, homeostasis and pathogenesis of many diseases (immune disorders, fibrosis, cancer…).

Upon binding to its receptors (T?RI and II), TGF? enables T?RII to transphosphorylate T?RI, which in turn activates the canonical Smad pathway (by phosphorylating Smad2 and Smad3 that further interact with Smad4 to accumulate inside the nucleus) and other signaling pathways (Mapk, RhoA, and Pi3K/Akt). L. Bartholin’s work on TGF? was initiated during his Master in 1998 and continued during his PhD from 1999 to 2002. During this period L. Bartholin contributed to characterizing direct transcriptional target genes of the newly identified canonical Smad signaling pathway of the TGF? family members (Follistatin, FLRG). During his PostDoc in 2003-2005 in the USA (University of Virginia, Charlottesville, VA), L. Bartholin applied his knowledge in cellular and molecular biology to the field of TGF? and Smad signaling to evaluate its role in vivoby generating TGIF knock out mice (TGIF is a Smad modulator). Back in France in 2006, L. Bartholin started his own lab at CRCL (Cancer Research Center of Lyon, France) in 2008 and focused his work on the role of TGF? in pancreatic ductal adenocarcinoma. To that end, he used and developed original genetically engineered mouse models. For instance, he investigated the role of transcriptional intermediary factor 1 gamma (Tif1?), which was described as a TGF? signaling modulator by others, he inactivated this gene in the pancreas of genetically engineered mice.

L. Bartholin has also generated a transgenic mouse strain that express a conditional constitutively activated TbRI receptor allowing to clarify the role of TGF? in the early step of pancreatic carcinogenesis. L. Bartholin’s scientific production started in 2000 and comprises 54 publications indexed in Pubmed (37/54 total publications are on TGF?) ORCID #:  0000-0002-5637-3223; ResearcherID :  Q-6655-2017).