Nicolas JONCKHEERE

I am a molecular and cellular biologist working on mucins for 15+ years and notably about the membrane bound O-glycoprotein MUC4 in pancreatic cancer. Pancreatic Ductal Adenocarcinoma (PDAC) cancer is the 4th leading cause of death by cancer in the world with an extremely low survival rate (6 months) and a short survival curve at 5 years (3%). We aim to understand the roles of the membrane bound mucin MUC4 and its partner, the oncogenic receptor ErbB2 and the cellular underlying mechanisms (cell signaling, miRNA) in pancreatic carcinogenesis. We are using a triple (in vitro, in vivo and ex vivo) approach to decipher their roles in the initiation of pancreatic carcinogenesis and in the resistance to chemotherapy.

 

  • 2012-today : Tenure Researcher Inserm CRCN, UMR-S1172 Team mucins, epithelial differentiation and carcinogenesis
  • 2007-12: Postdoctoral researcher Inserm UMR837 Team 5 "Mucins, epithelial differentiation and carcinogenesis"(Dir : Dr Isabelle Van Seuningen)
  • 2005-07: Postdoctoral researcher University of California Irvine, Dir. : Dr Maike Sander
  • 2000-2004 PhD Life and Health Sciences “Transcriptional regulation of human and murin mucins by TGF-b  and transcription factors involved in gastrointestinal differentiation”
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