Yvan Martineau

CRCM, Marseille

My current work is focused on the dysregulation of protein synthesis during pancreatic cancer development and treatment. We have identified the loss of a translation repressor, 4E-BP1, along pancreatic cancer development, in association with mTOR inhibitors resistance.

We are using genome-wide polysome-profiling (translatome) to decipher global change in mRNA translation, which allows the identification of dysregulated cellular processes and new therapeutic targets.

Using this approach, we showed that 4E-BP1-deficient tumor cells highly translate mRNAs encoding DNA replication and repair proteins. We are now analyzing translatome using in vitro and mouse models that incorporate the complex genetic and microenvironment of pancreatic cancer. .